Small cholangiocyte
Webb9 feb. 2024 · Collectively, DUOX2⁺ACE2⁺ small cholangiocytes are pathogenic targets in PBC, and preservation of DUOX2⁺ACE2⁺ cholangiocytes and targeting anti-pIgR autoantibodies may be valuable strategies for... WebbTo address this question, we analyzed the migration-based characteristics of these cells that may help to understand their functions in vivo. Interestingly, dibutyryl cAMP induced marked filopodia formation and cdc42 activation in the normal mouse cholangiocyte (NMC)-small cell line compared with the NMC-large cell line.
Small cholangiocyte
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WebbCholangiocytes carry out this function through a complex sensing mechanism mediated by a series of receptors, ion channels and sensory signaling molecules found on a structure known as a primary cilia that extends from the apical membrane of the cell into the lumen of the bile duct3. Webb21 dec. 2024 · Specifically, only small cholangiocytes proliferate when stimulated with a specific histamine receptor agonist (HRH1); however, small cholangiocytes can also acquire large cholangiocyte phenotypes after insult such as GABA treatment ( Francis et al., 2008; Mancinelli et al., 2013 ).
Webb17 mars 2010 · However, in the CCl 4 model of hepatotoxin induced liver damage both normal and BDL cholangiocytes are susceptible to damage. 39,40 Administration of an acute dose of CCl 4 to normal or BDL rats induces apoptosis of large cholangiocytes 39,40 (which line large ducts). 82,83 Small cholangiocyte (which line small ducts) 82,83 were … Webb1 feb. 2011 · Small cholangiocytes proliferate via activation of calcium (Ca2+)‐dependent signaling in response to pathological conditions that trigger the damage of large cyclic adenosine monophosphate–dependent cholangiocytes. Although our previous studies suggest that small cholangiocyte proliferation is regulated by the activation of …
Webb29 jan. 2024 · Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, ... Adaptive autoimmunity and cholangiocyte apoptosis is increased in PBC by over-activated Th1, Th2, and Th17 cells as a result of decreased immunosuppressive functions of regulatory T cells ... WebbSmall and large cholangiocytes express HRH1, CaMK I, and CaMK II. Small (but not large) cholangiocytes proliferate in response to HTMT dimaleate and are blocked by …
Webb12 juni 2024 · Interestingly, cholangiocyte-enriched transcription factors, Onecut1 and Onecut2, and cholangiocyte markers, Gpbar1 and Spp1, were significantly up-regulated in the HFM culture (figure 4(D)). Immunofluorescence analysis also confirmed that HFM-cultured CLCs maintained the expression of cholangiocyte markers (HNF1B, AQP1, …
Webb15 apr. 2016 · Unless noted otherwise, a small cholangiocyte cell line was used for spheroid culture as described previously. 19 Primary neonatal extrahepatic cholangiocytes were isolated by outgrowth from 0- to 3-day-old BALB/c mouse pup bile ducts as described previously and were used for spheroids when specified. 20 Primary cells were used at … flowy curly hairWebbCa(2+)-dependent protein kinase C (PKC) regulates small cholangiocyte function. Because gamma-aminobutyric acid (GABA) affects cell functions by activation of both Ca(2+) signaling and inhibition of AC, we sought to develop an in vivo model characterized by large cholangiocyte damage and proliferation of small ducts. flowy cursive fontWebb9 feb. 2024 · Cholangiocytes play a crucial role in bile formation. Cholangiocyte injury causes cholestasis, including primary biliary cholangitis (PBC). However, the etiology of … flowy curlsWebb15 aug. 2024 · Cholangiocyte phenotypes and ability to form bile ducts. Small cholangiocytes are a subset of cells that populate the biliary tree, and display a distinct … flowy cursive font generatorgreen county hardware grimsbyWebb27 nov. 2003 · Aims: We have shown that large and small cholangiocytes, which reside primarily in large and small intrahepatic bile ducts, respectively, have different functions and responses to injuries. However, there are no systematic studies of the molecular differences between small and large cholangiocytes, which would explain cholangiocyte … green county health department monroe wiWebb1 aug. 2008 · The stimulation of small cholangiocyte proliferation by HTMT dimaleate was blocked by the HRH1 antagonist terfenadine , the intracellular Ca 2+ chelator BAPTA/AM … green county health department illinois