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Maccannell fibroblast model

WebOct 25, 2015 · Simulations of F-M coupling pairs comparing coupling via dynamic Cx43, Cx45, and Cx43/Cx45 GJs to a static model. (a) Dynamic GJ models were used to couple the MacCannell fibroblast model to the ... WebIt consists of a highly detailed 3D geometric model of the atria (754,893 nodes and 515,005 hexahedral elements with a homogeneous resolution of 300 μm) coupled to a torso model (254,976 nodes and 1.5 M tetrahedral elements) made up of lungs, bones, liver, ventricles, blood, and general torso, see Figure 1A.

Computational modeling of cardiac fibroblasts and fibrosis

WebMacCannell et al. used computational models of cell pairs using the Tusscher-Noble-Noble-Panfilov (TNNP) model of the human ventricular cardiomyocyte and their active … WebNov 11, 2014 · The Ramirez-Nattel-Courtemanche (RNC) ionic model of canine atrial cardiomyocyte action potentials (APs) ( 25) was implemented and electrically connected to a variable number ( n) of MacCannell model fibroblasts ( 20) via gap junctions of conductance G gap. The total ionic current for the RNC model (I ion,RNC) is greggs chancery lane https://spumabali.com

The Role of Fibroblasts in Complex Fractionated …

WebThe active force of fibroblasts was therefore ignored at the cellular level in this study. 2.1.3 Tissue modeling With the above mentioned cellular electrome- chanical models for myocytes and fibroblasts, both AP and Tacan be computed and then incorporated into the following tissue models. WebAug 23, 2016 · We patch-clamped guinea pig ventricular cardiomyocytes and used the dynamic-clamp technique to couple them to the MacCannell fibroblast electrophysiology model ( 27) via GJ channel models developed to represent the gating and kinetic properties of Cx43, Cx45, and Cx43/Cx45. WebA mathematical model of the electrophysiological properties of adult ventricular fibroblast was developed and then integrated with the ten Tusscher model of the human ventricular myocyte ( 14. ). Linear resistive coupling was chosen as the basis for intercellular electrotonic interactions. greggs chairman

Frontiers Mechano-Electric Coupling and Arrhythmogenic Current ...

Category:A model of electrical conduction in cardiac tissue …

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Maccannell fibroblast model

Computational Approaches to Understanding the Role of Fibroblast ...

WebMar 1, 2014 · In this study, the effects of cardiac fibroblast proliferation on cardiac electric excitation conduction and mechanical contraction were investigated using a proposed integrated myocardial-fibroblastic electromechanical model. At the cellular level, models of the human ventricular myocyte and fibroblast were modified to incorporate a model of … WebNov 18, 2014 · The total ionic current for the MacCannell fibroblast model (I ion,fb) is calculated as I ion, fb = I Kv, fb + I Kir, fb + I NaK, fb + I b, Na, fb − I gap where I Kv,fb and I Kir,fb are the fibroblast-delayed-rectifier and inward-rectifier K + currents, respectively, I NaK,fb is the Na + /K + exchange pump current, I b,Na,fb is the background Na …

Maccannell fibroblast model

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WebPubMed WebFeb 16, 2012 · MacCannell et al. 27 have demonstrated that the myocyte action potential duration (APD) is shortened when it is coupled to fibroblasts due to the depolarization caused by their higher resting...

WebFeb 16, 2007 · First, fibroblasts were modeled as a spherical cell with a capacitance of 6.3 pF and an ohmic membrane resistance of 10.7 GΩ. When these “passive” fibroblasts …

WebA Mathematical Model of Electrotonic Interactions between Ventricular Myocytes and Fibroblasts K. Andrew MacCannell,* Hojjat Bazzazi,* Lisa Chilton,* Yoshiyuki Shibukawa,* Robert B. Clark,* and Wayne R. Giles*y *Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; andyFaculty of WebIonic channel currents of the atrial fibroblast model. (A–C) The simulated I-V curves for the major ionic currents (solid lines) are shown along with the respective experimental data …

WebNov 11, 2014 · The total ionic current for the MacCannell fibroblast model (I ion,fb) is calculated as I ion,fb = I Kv,fb + I Kir,fb + I NaK,fb + I b,Na,fb − I gap where I Kv,fb and I …

WebIn the MacCannell model, four membrane ion currents are considered for fibroblasts: a time- and voltage-dependent “delayed-rectifier” K + current iKv, an inward-rectifying K + … greggs charity workWebWe modeled the BZ in eight different ways by combining the presence or absence of electrical remodeling with four different levels of image-based patchy fibrosis (0, 10, 20, and 30%). A 3D torso model was also constructed to compute the ECG. Patient-specific sinus activation patterns were simulated and validated against the patient's ECG. greggs charing crossWebJan 20, 2024 · The electrophysiological properties for the fibroblasts are described using the MacCannell “active” fibroblast model 25. greggs charity foundation