WebOct 25, 2015 · Simulations of F-M coupling pairs comparing coupling via dynamic Cx43, Cx45, and Cx43/Cx45 GJs to a static model. (a) Dynamic GJ models were used to couple the MacCannell fibroblast model to the ... WebIt consists of a highly detailed 3D geometric model of the atria (754,893 nodes and 515,005 hexahedral elements with a homogeneous resolution of 300 μm) coupled to a torso model (254,976 nodes and 1.5 M tetrahedral elements) made up of lungs, bones, liver, ventricles, blood, and general torso, see Figure 1A.
Computational modeling of cardiac fibroblasts and fibrosis
WebMacCannell et al. used computational models of cell pairs using the Tusscher-Noble-Noble-Panfilov (TNNP) model of the human ventricular cardiomyocyte and their active … WebNov 11, 2014 · The Ramirez-Nattel-Courtemanche (RNC) ionic model of canine atrial cardiomyocyte action potentials (APs) ( 25) was implemented and electrically connected to a variable number ( n) of MacCannell model fibroblasts ( 20) via gap junctions of conductance G gap. The total ionic current for the RNC model (I ion,RNC) is greggs chancery lane
The Role of Fibroblasts in Complex Fractionated …
WebThe active force of fibroblasts was therefore ignored at the cellular level in this study. 2.1.3 Tissue modeling With the above mentioned cellular electrome- chanical models for myocytes and fibroblasts, both AP and Tacan be computed and then incorporated into the following tissue models. WebAug 23, 2016 · We patch-clamped guinea pig ventricular cardiomyocytes and used the dynamic-clamp technique to couple them to the MacCannell fibroblast electrophysiology model ( 27) via GJ channel models developed to represent the gating and kinetic properties of Cx43, Cx45, and Cx43/Cx45. WebA mathematical model of the electrophysiological properties of adult ventricular fibroblast was developed and then integrated with the ten Tusscher model of the human ventricular myocyte ( 14. ). Linear resistive coupling was chosen as the basis for intercellular electrotonic interactions. greggs chairman