Irf4 and b cell

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August undefined, 2024

WebDec 2, 2024 · B cells, or B lymphocytes, are an important and complex cell type that plays central roles in humoral immunity against infections, autoimmunity and transplantation. ... CD24– as well as by the expression of transcription factors BLIMP1, XBP1, and IRF4. In addition, plasma cells express high levels of CD138 (SDC1). ... WebApr 8, 2024 · These cells showed a downregulation of Pax5 compared to other B cells. Within Blimp-1 + IRF4 + B cells, IgM-, IgG-, and IgA-expressing cells were identified and immunoglobulin-class distribution was clearly different between the anatomical locations, with IgA + PCs dominating in lung tissue and IgM + PCs dominating in the spleen. …

3662 - Gene ResultIRF4 interferon regulatory factor 4 [ (human)]

WebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is … WebMay 16, 2013 · The transcription factor IRF4 regulates immunoglobulin class switch recombination and plasma cell differentiation. Its differing concentrations appear to … can dry waxed paper go in oven

Signals that drive T-bet expression in B cells - PMC

WebAug 10, 2024 · To explore the role of IRF4 in orchestrating B-cell differentiation trajectories in more detail, we adoptively transferred CTV-labeled Cd19 Cre/+ Irf4 fl/fl (IRF4 –/–) B … WebIRF4 is a member of the interferon regulatory factor (IRF) family of transcription factors and exerts critical functions in various cell types of the immune system (De Silva et al., 2012).In the B cell lineage, IRF4 is expressed in all developmental stages, with the exception of germinal center (GC) B cells (Falini et al., 2000; Cattoretti et al., 2006). WebNov 22, 2024 · IRF4 is also required in B cells for germinal center formation and plasma cell differentiation ( 14 – 16 ). Because of IRF4’s unique role in mature B cells, we … can drywood termites be eliminated

IRF4 ablation in B cells abrogates allogeneic B cell …

JP7239597B2 - Regulators of IRF4 expression - Google Patents

WebJan 19, 2024 · IRF4 regulates the immunosuppressive function of Tregs in primary immune thrombocytopenia [ 19 ]. IRF4 participates in the regulation of immune response and the development metabolism of immune cells [ 20 ]. More importantly, IRF4, as an upstream transcription factor of BCL6, negatively regulates the expression of BCL6 [ 21 ]. WebOnce a B cell is within the quiescent mature follicular (FO) or marginal zone (MZ) pools, these transcriptional programs are maintained at steady state unless activating signals are received. 2. Activation initiates transcriptional program shifts fish tales pinball restorationWebApr 4, 2024 · IRF4 is highly expressed in B cells and plasma cells where it plays essential roles in controlling B cell to plasma cell differentiation and immunoglobulin class switching. Overexpression of IRF4 is found in MM patients' derived cells, often as a result of activating mutations or translocations, where it is required for their survival. can dryzone treated brickwork be painted

"WebJul 23, 2024 · In mice lacking Irf4, B and T cells were unable to proliferate in response to B cell receptor (BCR), T cell receptor (TCR), CD40, or LPS stimulation . Studies in mice revealed that Irf4 is necessary for AID upregulation, class-switch recombination (CSR), and generation of plasma cells in response to BCR signaling (5, 26, 27). " - Irf4 and b cell

Irf4 and b cell

IRF4 and BATF are critical for CD8 + T-cell function following

WebIRF4 is a gene located on chromosome 6 that encodes for the IRF4 protein belonging to the IRF family of transcription factors. Large B-cell lymphoma with IRF4 rearrangement … WebApr 30, 2009 · IRF4 regulatory networks in B-cell differentiation and malignancy. IRF4 lies at the center of regulatory networks that function at several stages of B-cell differentiation and drive malignancy. A, in resting mature B cells, IRF4 levels are low or absent due to MITF repression of the IRF4 gene.

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WebApr 14, 2024 · T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as … WebThe inducible deletion of Irf4 specifi- cally in mature B cells revealed that IRF4 regulates NOTCH2-mediated homing of mature B cells either in MZ or FO compartment of the spleen (Simonetti et al ...

WebApr 13, 2024 · The family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) features only a few major changes as compared to the 4th edition. ... Klapper, W. Experience with provisional WHO-entities large B-cell lymphoma with IRF4-rearrangement and Burkitt ... WebApr 11, 2024 · While there are also reports that B cell receptor and TCR signaling induces transient PS exposure on the cell surface ... Ifng, Irf4, Tnf, and Nr4a1 in EV + CD8 + T cells. Especially the effector cytokines IFN-γ and TNF-α are NFATc1 dependent . CD8 + T E cells are central to fight viral infection by cytotoxic lysis of infected cells .

WebJan 1, 2015 · Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL). The interferon regulatory factor 4 (IRF4) is known to be highly expressed in both ALK + and ALK − ALCLs. However, the role of IRF4 in the … WebFeb 14, 2014 · The interferon regulatory factor 4 (IRF4) is an important immunological transcription factor required for B-cell maturation 3 and for the maintenance of various CD4 + T-cell subsets...

WebApr 26, 2024 · Author summary EBV is an important cause of human B-cell malignancies and transforms B cells in vitro. Although there are two different types of EBV (T1 and T2), most research has been performed using T1 strains and much less is known about how T2 EBV interacts with B cells. T2 EBV is most frequently found in regions of Africa where …

WebMar 1, 2024 · IRF4/MUM1 has been well known for its strong expression in many B-cell neoplasms such as non-GCB type diffuse large B-cell lymphoma (DLBCL), classic Hodgkin … fish tales pinball pinsideWebNov 14, 2024 · Here we describe a novel mechanism of CLL tumor immune evasion that is independent of T-cell exhaustion, using B-cell–specific deletion of the transcription factor … fish tales restaurant 78247WebOur recent work demonstrated that IRF4 and SPIB are epigenetic targets of JAK1 due to H3Y41 phosphorylation, but IRF4 expression is not regulated by STAT3 ( 3 ). These findings along with the above RNA-seq analysis prompted us to investigate whether STAT3 directly targets critical genes in the IFNβ signaling pathway. can drywall be paintedWebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell … can drywall mud moldWebDec 1, 2024 · The overexpression of MUM1 is often activated by IRF4 rearrangement which was mainly reported in multiple myeloma [5] and was first reported in B-cell lymphoma in 2011(2).Immunohistochemical staining of MUM1 was positive in 50%–70% of LBCLs, while the incidence of IRF4 rearrangement in LBCL originating from Waldeyer’s ring is only 8% [6 … c and s alliance pty ltd mount gambierWebMar 20, 2024 · It has been shown that IRF8 and SPI1 may contribute to BCL6 induction in antigen-engaged pre-GC-B cells, while IRF4 and PRDM1 repress BCL6 in light zone GC-B cells (16, 48). Moreover, the binding of BCL6 to its own 5′ regulatory region forms an autoregulatory circuit that limits its own expression in GC-B cells (Figure 2C) . c and s ambulance vandergrift paWebMay 24, 2024 · We report two transcription factors, IRF4 and STAT3, as regulators of the gene expression in response to PM exposure in human. We confirmed that the activation of IRF4 and STAT3 by PM is strongly associated with imbalanced differentiation of T-cells in the respiratory tracts in a time-sensitive manner in mouse. fish tales pinball ramp