Impact of mirna in atherosclerosis

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August undefined, 2024

Witryna17 gru 2024 · This study presents novel evidence linking miR-155 biology with the progression and regression of atherosclerosis. Herein, we have shown an inverse … WitrynaAtherosclerosis is a condition caused by lipid-induced inflammation of the vessel wall orchestrated by a complex interplay of various cell types, such as endothelial cells, smooth muscle cells, and macrophages. ... we outline the effects of miRNA-145, -126, and -155 in atherosclerosis in vivo. Downregulation of miR-145, which controls ...

MicroRNA-155 promotes the ox-LDL-induced activation of NLRP3 ...

WitrynaAtherosclerosis and lipid biology. Adenylate cyclase type 9 antagonizes cAMP accumulation and regulates endothelial signalling involved in atheroprotection. ... Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure. Coraline Heron, Anais Dumesnil, Mahmoud Houssari, ... Witryna27 lip 2024 · These findings imply that miR-142-5p may plays a role in the development of atherosclerosis. Next, we tested the effect of miR-142-5p on the 3′-UTR of ABCA1 using luciferase reporter constructs and demonstrated that miR-142-5p dose-dependently reduced mouse and human ABCA1 3′-UTR activities (Figure S11A and … devilbiss spray gun light

Biomedicines Free Full-Text Inflammatory Mechanisms …

Witryna9 maj 2024 · microRNAs (miRNAs) are implicated in the development of a wide range of diseases, including atherosclerosis, obesity, and diabetes (5–8).Among these miRNAs, aberrant let-7 expression is associated with diseases including liver and lung fibrosis and cancer (9,10).In the context of diabetes-associated atherosclerosis (DAA), previous … WitrynaThis review highlights the impact of microRNA-33-mediated regulation in the major cardiometabolic risk factors of atherosclerosis including lipid metabolism (HDL biogenesis and cholesterol homeostasis, fatty acid, phospholipid and triglyceride, bile acids metabolism), inflammatory response, insulin signaling and glucose/energy … WitrynaHere, we aimed to screen the atherosclerosis-associated miRNAs and preliminarily investigate the potential regulatory mechanism of... Endothelial Cells, Atherosclerosis and Mesenchymal Cells ... church font

MicroRNA-186-5p serves as a diagnostic biomarker in …

Impact of miRNA in Atherosclerosis Arteriosclerosis, Thrombosis, …

WitrynaDownload scientific diagram The screened miR-342-5p facilitated the apoptosis of HUVECs impaired by H2O2. (A) The heat map of top-30 upregulated miRNAs ranked by log2FC value in RNA-sequencing ... WitrynaAtherosclerosis is a hallmark of cardiovascular disease, and lifestyle strongly impacts its onset and progression. Nutrients have been shown to regulate the miR-17/92 cluster, with a role in endothelial function and atherosclerosis. Choline, betaine, and L-carnitine, found in animal foods, are metabolized into trimethylamine (TMA) by the gut … church follow up letter examplesWitryna13 maj 2024 · In addition, the effect of miR-100-5p on the SMAD7 expression was only evident upon combined treatment in HASMCs. Interestingly, the effect of miR-100-5p … devilbiss spray gun rebuild kits

"Witryna19 sie 2024 · Atherosclerosis remains the leading cause of a broad spectrum of deadliest cardiovascular diseases. MicroRNA‐33 is a new therapeutic target for atherosclerosis due to its diverse functions. However, it remains a great challenge in clinical translation of nucleic acid‐based microRNA‐targeting therapeutics. … " - Impact of mirna in atherosclerosis

Impact of mirna in atherosclerosis

Frontiers Epigenetic Regulation in Pathology of Atherosclerosis: …

Witryna24 cze 2024 · The inhibition of miR-33 using pHLIP-directed macrophage targeting improves atherosclerosis regression by increasing collagen content and decreased … Witryna24 mar 2024 · Atherosclerosis (AS) is a chronic arterial disorder and a significant determinant of vascular death [].Fatty streaks in arterial walls regularly develop into characteristic plaques and atheroma [].The acute rupture of these atheromatous plaques leads to local thrombosis, causing partial or total occlusion of the affected artery [].AS …

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Witryna26 mar 2024 · Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to … Witryna29 lis 2024 · MiR-155 is an important microRNA that modulates inflammation in atherosclerosis, but the role of miR-155 in the regulation of the NLRP3 inflammasome is still unknown. ... Corbalan-Campos J, et al. Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on …

WitrynaScience Volunteer Witryna5 paź 2024 · A novel polymer that can target vascular cell adhesion molecule-1 protein (β-amino ester) NP specifically delivers anti-microRNA-712 (anti-miR-712) to inflammatory endothelial cells and reduces the high expression of pro-atherosclerotic miR-712, thus protecting from atherosclerosis. 114 Nguyen et al. developed …

Witryna14 kwi 2024 · It should be noted that miR-10b expression is altered in whole human arteries affected by atherosclerosis [37, 40]. Mir10b knockout mice were resistant to … Witryna20 mar 2024 · Background: Atherosclerosis (AS) is a major risk factor for cardiovascular disease. microRNAs play a key role in gene regulation in the formation and …

Witryna22 lip 2024 · The authors hypothesized that ACP5, as a direct target of lncRNA-H19, causes atherosclerosis by affecting cellular proliferation and apoptosis (Huang et al. 2024). Many studies have reported that lncRNA-H19 functions as a ceRNA to sponge its target miRNAs such as microRNA let-7 (Hsu et al. 2014; Sun et al. 2024b; Cao et al. …

WitrynaMiRNA controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ, and plays the roles in endothelial cell (EC), vascular smooth … church font dafontWitryna19 lut 2016 · Over the past decade, microRNAs (miRNAs) have emerged as evolutionarily conserved, noncoding small RNAs that serve as important regulators … devilbiss spray gun tipsWitrynaBACKGROUND: Oxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/humoral abnormalities and bi devilbiss starting line manualWitryna21 kwi 2024 · MicroRNA dysregulation occurs in many human diseases, including atherosclerosis. Here, we examined the serum expression and clinical significance … devilbiss spray guns south africaWitryna20 mar 2013 · MicroRNAs (miRNAs) are small, ~22 nucleotide (nt) sequences of RNA that regulate gene expression at posttranscriptional level. These endogenous gene expression inhibitors were primarily described in cancer but recent exciting findings have also demonstrated a key role in cardiovascular diseases (CVDs), including … devilbiss sri pro parts breakdownWitrynaInhibition of miR-33 results in increased cholesterol efflux and HDL-cholesterol levels in mice. In this study we examined the effect of miR-33 inhibition in a mouse model of atherosclerosis and observed significant reduction in atherosclerotic plaque size. At the end of the study, gene expression in macrophages from the atherosclerotic plaques … devilbiss spray guns finish lineWitrynaAtherosclerosis is closely related to vascular dysfunction and hypertension. Ojeoksan (OJS), originally recorded in an ancient Korean medicinal book named “Donguibogam”, is a well-known, blended herbal formula. This study was carried out to investigate the … church font for sale uk