WebAug 1, 2014 · The toxicity of dichlorvos (DDVP), an organophosphate (OP) pesticide, classically results from modification of the serine in the active sites of cholinesterases. However, DDVP also forms adducts on unrelated targets such as transferrin and albumin, suggesting that DDVP could cause perturbations in cellular processes by modifying ... WebApr 30, 2013 · The role of calcium homeostasis in dichlorvos toxicity is another area where the data do not provide a clear answer but are very suggestive. There are numerous calcium dependent processes that are perturbed by the exposure. For example, the gene encoding UNC-43, a calmodulin-dependent protein kinase that can activate the p38/PMK …
Dichlorvos-induced testicular toxicity in male rats and the …
WebBasis for revised IDLH: The revised IDLH for dichlorvos is 100 mg/m 3 based on an analogy to parathion. Since the toxicity of dichlorvos is about 10 times lower than parathion (based on acute oral toxicity data in animals), the revised IDLH for dichlorvos is 10 times the revised IDLH for parathion (10 mg/m 3). WebFeb 27, 2024 · Acute OP toxicity is caused by inhibiting the acetylcholinesterase (AChE) enzyme, resulting in a cholinergic surge. It is treated with atropine and pralidoxime. Our case is a patient with a past history of sleeve gastrectomy and intestinal bypass surgery presented after oral OP intake. ... Dichlorvos, an organophosphorus (OP) compound, is … ironton truck tool box
The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity ...
WebOrgan toxicity: Dichlorvos primarily affects the nervous system through cholinesterase inhibition, the blockage of an enzyme required for proper nerve functioning. Fate in … WebOct 11, 2012 · The aim of this study was to examine the effects of ubiquinone (CoQ10) on heart tissue and erythrocytes in acute organophosphate poisoning (AOP). A total of 20 rabbits were divided into three groups: sham (n = 8), pralidoxime (PAM) + atropine (n = 6), and CoQ10 + PAM + atropine (n = 6). Blood samples were taken from each test subject … WebDichlorvos (O, O-dimethyl O-(2,2-dichlorovinyl phosphate: DDVP 76.6 X EC) an organophosphate pesticide had a profound effect on cardiac activity of albino rats. Adult male rats anesthetized with pentobarbitone were administered 30, 50, 70 and 90 mg/kg body weight of dichlorvos. The heart rate and el … ironton tower house